STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF

• Main Authors: MOYER, James, D, NORRIS, Timothy, FOSTER, Barbara, A, KAJIJI, Shama, M, MORIN, Michael, J, FERRANTE, Karen, J, SILBERMAN, Sandra, L, RAGGON, Jeffrey, W, CONNELL, Richard, D
• Format: Patent
• Language: English; French; German
• Published: 10.05.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SEPARATION; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRANSPORTING

Predmetni pronalazak odnosi se na stabilni kristalni oblik N-(3-etinilfenil)-6,7-bis(2-metoksietoksi)-4-kvinazolinamin hidrohlorida označen kao polimorf B, njegove produkte u esencijalno čistom obliku i njegovu upotrebu. Pronalazak se takođe odnosi na farmaceutske preparate koji sadrže stabilni oblik polimorfa B N-(3-etinilfenil)-6,7-bis(2-metoksietoksi)-4-kvinazolinamina kao hidrohlorid, kao i druge oblike jedinjenja i njihovu upotrebu kod tretiranja hiperproliferativnih poremećaja kao što je kancer. The invention provides a compound comprising N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, or a pharmaceutically acceptable salt thereof in anhydrous or hydrate form for use in the treatment of NSCLC (non small cell lung cancer).