Polycyclic-carbamoylpyridone compounds and their pharmaceutical use

• Main Authors: MORGANELLI Philip Anthony, COTTELL Jeromy J, LAZERWITH Scott E, MISH Michael R, DESAI Manoj C, JIN Haolun, BACON Elizabeth M, CAI Zhenhong R, JI Mingzhe, CHEN Xiaowu, TREJO MARTIN Teresa Alejandra, TAYLOR James G, PYUN Hyung-Jung
• Format: Patent
• Language: English; Romanian; Russian
• Published: 31.01.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to polycyclic carbamoylpyridone compounds with the following Formula (I):(I),including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1 and Z4 are as defined in the present document. The claimed compounds may be used in the treatment of human immunodeficiency virus (HIV) infection. Invenţia se referă la compuşi policiclici de carbamoilpiridonă cu următoarea formulă (I):(I),inclusiv stereoizomeri şi săruri acceptabile farmaceutic ale acestora, în care R1, X, W, Y1, Y2, Z1 şi Z4 sunt definiţi în prezentul document. Compuşii revendicaţi pot fi utilizaţi în tratamentul infecţiei cu virusul imunodeficienţei umane (HIV). Изобретение относится к полициклическим соединениям карбамоилпиридона со следующей формулой (I):(I),включительно стереоизомеры и их фармацевтически приемлемые соли, где R1, X, W, Y1, Y2, Z1 и Z4 определены в данном документе. Заявленные соединения могут быть применены в лечении инфекции вирусом иммунодефицита человека (ВИЧ).