Positive allosteric modulators of nicotinic acetylcholine receptor

• Main Authors: ESKILDSEN Jǿrgen, PÜSCHL Ask, SAMS Anette Graven
• Format: Patent
• Language: English; Romanian; Russian
• Published: 30.06.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to cyclopropanecarboxamide derivatives of formula (I):(I)wherein R6 is hydroxymethyl, A8 is N, and R1-R5, R10, R11, A7 and A9 are as defined in the disclosure of the invention.The invention also relates to compositions comprising said compounds, and to methods of treating diseases comprising their administration. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor. Prezenta invenţie se referă la derivaţi de ciclopropancarboxamidă cu formula (I):(I)unde R6 reprezintă hidroximetil, A8 reprezintă N, şi R1-R5, R10, R11, A7 şi A9 sunt definiţi în descrierea invenţiei.Invenţia se referă, de asemenea la compoziţii, care conţin compuşii menţionaţi şi la metode de tratament al afecţiunilor, care includ administrarea acestora. Compuşii menţionaţi reprezintă modulatori alosterici pozitivi (PAM) ai receptorului α7 nicotinic al acetilcolinei. Настоящее изобретение относится к производным циклопропанкарбоксамида формулы (I):(I)где R6 является гидроксиметилом, A8 является N, и R1-R5, R10, R11, A7 и A9 определены в описании изобретения.Изобретение также относится к композициям, содержащим вышеуказанные соединения, и к способам лечения заболеваний, включающим их прием. Упомянутые соединения являются позитивными аллостерическими модуляторами (РАМ) никотинового α7-рецептора ацетилхолина.