Tenofovir alafenamide hemifumarate and its medical uses

• Main Authors: YU, Richard, Hung Chiu, WANG Fang, SHI Bing, LIU, Dazhan
• Format: Patent
• Language: English; Romanian; Russian
• Published: 31.03.2018
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a hemifumarate form of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine (tenofovir alafenamide) of Formula (I) and antiviral therapy using (I), for example, in anti-HIV and anti-HBV therapies. Prezenta invenţie se referă la o formă de hemifumarat de 9-[(R)-2-[[(S)-[[(S)-1-(izopropoxicarbonil)etil]amino]fenoxifosfinil]metoxi]propil] adenină (tenofovir alafenamidă) cu formula (I) şi la terapia antivirală folosind (I), de exemplu, în tratamentul infecţiilor cu HIV şi HBV. Настоящее изобретение относится к форме гемифумарата 9-[(R)-2-[[(S)-[[(S)-1-(изопропоксикарбонил)этил]амино]феноксифосфинил]метокси]пропил] аденина (тенофовира алафенамида) с формулой (I) и к антивиральной терапии с использованием (I), например, в лечении ВИЧ и HBV инфекций.