Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]

• Main Authors: SUCMAN Natalia, MACAEV Fliur
• Format: Patent
• Language: English; Romanian, Moldovan; Russian
• Published: 30.09.2013
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention relates to the synthesis of carbonitrile derivatives of spiro[cyclopropane-oxindoles], which can serve as precursors in the synthesis of substances with anti-HIV activity.The process involves the reaction of cyclopropanation of diazoisatins with acrylonitrile, used both as reagent and solvent at its boiling point.The proposed process allows of carrying out the reaction in a shorter time with high yields, without the use of catalysts and inert atmosphere. Invenţia se referă la sinteza derivaţilor carbonitrilici ai spiro[ciclopropan-oxindolilor], care pot servi ca precursori în sinteza substanţelor cu activitate anti-HIV.Procedeul include reacţia de ciclopropanare a diazoizatinelor cu acrilonitril, utilizat atât în calitate de reagent, cât şi de solvent la temperatura de fierbere a lui.Procedeul propus permite efectuarea reacţiei într-un timp mai scurt, cu randamente înalte, fără utilizarea catalizatorilor şi a atmosferei inerte. Изобретение относится к синтезу карбонитрилпроизводных спиро[циклопропан-оксиндолов], которые могут служить прекурсорами в синтезе веществ с анти-ВИЧ активностью.Способ включает реакцию циклопропанирования диазоизатинов с акрилонитрилом, используемого как в качестве реагента, так и растворителя при температуре его кипения.Предложенный способ позволяет более быстрое проведение реакции с высокими выходами, без использования катализаторов и инертной атмосферы.