Process for extraction of glaucine halogene hydrates from Glaucium flavum

• Main Authors: VLAD PAVEL, BARBA ALIC, MIRONOV GRIGORE, DRAGALIN ION, CIOCARLAN ALEXANDRU, COLTA MIHAIL
• Format: Patent
• Language: English; Romanian
• Published: 30.07.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Inventia se refera la procedeele de extractie a compusilor biologic activi din materie prima vegetala in scopuri farmacologice, in particular la un procedeu de extractie a halogenhidratilor glaucinei din Glaucium flavum. Procedeul, conform inventiei, include maruntirea partilor aeriene ale plantelor, extractia materiei prime cu apa la un raport de 1:5 la temperatura de 10...100°C si agitare continua, timp de 1...10 ore, filtrarea extractului apos, alcalinizarea extractului si extractia lui cu un solvent organic, decantarea fazei organice, distilarea partiala a solventului organic in vid si tratarea solutiei ramase cu clorura de hidrogen sau bromura de hidrogen cu sedimentarea cristalelor de sare, filtrarea, spalarea si uscarea lor. The invention relates to processes for extraction of biologically active compounds from plant raw material for pharmacological purposes, in particular to a process for extraction of glaucine halogene hydrates from Glaucium flavum.The process, according to the invention, includes shredding of aboveground plant parts, extraction of raw material with water in a ratio of 1:5 at a temperature of 10...100°C and constant stirring for 1...10 hours, filtration of water extract, alkalinization of extract and its extraction with an organic solvent, separation of organic phase, partial distillation of organic solvent in vacuum and treatment of the residual solution with hydrogen chloride or hydrogen bromide with the deposition of salt crystals, their filtration, washing and drying.