Method for preventing variceal hemorrhages in patients with decompensated liver cirrhosis

• Main Authors: ANGHELICI Gheorghe, ZUGRAV Tatiana, PISARENCO Sergiu, CRUDU Oleg, SAVIN Oleg
• Format: Patent
• Language: English; Romanian; Russian
• Published: 31.05.2022
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention relates to medicine, in particular to hepatology and can be used for the prevention of variceal hemorrhages in patients with decompensated liver cirrhosis.Summary of the invention consists in that endoscopically, two components of fibrin glue are simultaneously introduced into the lumen of the varicose vein, namely, the first component comprises a fibrinogen solution, and the second component comprises a mixture of thrombin solutions with a 10% solution of albumin, aprotinin and Ca+2 chloride, with the following ratio of components, per 1 dose of fibrin glue:fibrinogen solution (mg)15...45thrombin solution (IU)25...100albumin solution 10% (mL)10...20aprotinin solution (KIU)250...1000Ca+2 chloride solution (µmol)15...30. Invenţia se referă la medicină, în special la hepatologie şi poate fi utilizată pentru profilaxia hemoragiilor variceale la bolnavii cu ciroză hepatică decompensată.Esenţa invenţiei constă în aceea că endoscopic concomitent se injectează în lumenul varicelui două componente ale unui adeziv fibrinic şi anume, primul component include o soluţie de fibrinogen, iar al doilea component include un amestec de soluţii de trombină cu soluţie de albumină de 10%, aprotinină şi clorură de Ca+2, în următorul raport al componentelor, la 1 doză de adeziv:soluţie de fibrinogen (mg)15...45soluţie de trombină (UI)25...100soluţie de albumină de 10% (ml)10...20soluţie de aprotinină (KIU)250...1000soluţie de clorură de Ca+2(µmol)15...30. Изобретение относится к медицине, в частности к гепатологии и может быть использовано для профилактики варикозных кровотечений у больных с декомпенсированным циррозом печени.Сущность изобретения состоит в том, что эндоскопически одновременно вводят в просвет варикозно расширенной вены два компонента фибринового клея, а именно первый компонент включает раствор фибриногена, а второй компонент включает смесь растворов тромбина с 10%-ым раствором альбумина, апротинина и хлорида Са+2, при следующем соотношении компонентов, на 1 дозу фибринового клея:раствор фибриногена (мг)15...45раствор тромбина (ЕД)25...100раствор альбумина 10% (мл)10...20раствор апротинина (АКЕ)250...1000раствор хлорида Са+2 (мкмоль)15...30.