COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DE TROUBLES NEUROCOGNITIFS

Described herein are compositions and methods for treating a subject having or at risk of developing a neurocognitive disorder, such as Alzheimer's disease or Nasu-Hakola disease. For example, using the compositions and methods of the disclosure, a subject having or at risk of developing a neur...

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Bibliographic Details
Main Authors MASON, Chris, COOPER, Oliver, VAN TIL, Nico Peter, DEANDRADE, Mark, PLASSCHAERT, Robert
Format Patent
LanguageFrench
Published 08.12.2021
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Summary:Described herein are compositions and methods for treating a subject having or at risk of developing a neurocognitive disorder, such as Alzheimer's disease or Nasu-Hakola disease. For example, using the compositions and methods of the disclosure, a subject having or at risk of developing a neurocognitive disorder may be administered one or more cells that contain a transgene encoding triggering receptor expressed on myeloid cells two (TREM2), such as a population of CD34+ hematopoietic stem or progenitor cells that express TREM2, thereby treating or preventing the disorder.
Bibliography:Application Number: MA20200054873