PROCÉDÉS SYNTHÉTIQUES AMÉLIORÉS DE PRODUCTION DE COMPOSÉS HÉTÉROCYCLIQUES FUSIONNÉS UTILISÉS EN TANT QUE MODULATEURS DU RÉCEPTEUR DE L'OREXINE

Processes for preparing (((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanoneare described, which are useful for commercial manufacturing. Said compound is an orexin receptor modulator and may be useful in pharmaceutical...

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Bibliographic Details
Main Authors GALA, Dinesh, DEPRÉ, Dominique Paul Michel, HUYGAERTS, Andy Josephina Joannes, MATCHA, Kiran, MOENS, Luc Jozef Raphael
Format Patent
LanguageFrench
Published 23.02.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Processes for preparing (((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanoneare described, which are useful for commercial manufacturing. Said compound is an orexin receptor modulator and may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia and depression.
Bibliography:Application Number: MA20190054250