2,4-DIAMINO-QUINOLÉINE SUBSTITUÉE EN TANT QUE NOUVEAU MÉDICAMENT POUR LA FIBROSE, L'AUTOPHAGIE ET LES MALADIES ASSOCIÉES AUX CATHEPSINES B (CTSB), L (CTSL) ET D (CTSD)

The present invention relates to novel 2-primary amino-4-secondary amino-quinoline derivatives, their manufacture, pharmaceutical compositions comprising them and their use as medicaments. The active compounds of the present invention can be useful as a medicament in the treatment and/or the decreas...

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Bibliographic Details
Main Authors RACHID, Madani, BRUN, Sonia, COURCAMBECK, Jérôme, HALFON, Philippe, BASSISSI, Firas
Format Patent
LanguageFrench
Published 15.12.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel 2-primary amino-4-secondary amino-quinoline derivatives, their manufacture, pharmaceutical compositions comprising them and their use as medicaments. The active compounds of the present invention can be useful as a medicament in the treatment and/or the decreasing and/or the prevention of fibrosis and/or fibrosis related diseases, or for use as a medicament in the treatment and/or the decreasing and/or the prevention of the autophagy and/or autophagy related diseases and for the inhibition of the autophagy flux, or for use in the inhibition of cathepsins B (CTSB), L (CTSL) and/or D (CTSD) and/or cathepsins B (CTSB), L (CTSL) and/or D (CTSD) related diseases; with the proviso that said compounds are not to be used for the treatment of any forms of cancers.
Bibliography:Application Number: MA20190053540