PROCÉDÉ DE GÉNÉRATION DE COMPOSITIONS THÉRAPEUTIQUES DE CELLULES MODIFIÉES
The present disclosure provides methods for genetically engineering T cells, such as CD4+ T cells, for use in cell therapy. In some aspects, the provided methods include one or more steps for incubating the cells under stimulating conditions, introducing a recombinant polypeptide to the cells throug...
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Main Authors | , , , , , , , , , |
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Format | Patent |
Language | French |
Published |
09.09.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The present disclosure provides methods for genetically engineering T cells, such as CD4+ T cells, for use in cell therapy. In some aspects, the provided methods include one or more steps for incubating the cells under stimulating conditions, introducing a recombinant polypeptide to the cells through transduction or transfection, and cultivating the cells under conditions that promote proliferation and/or expansion. In some aspects, the incubation and/or the cultivation is performed in the presence of recombinant IL-2. In some aspects, the provided methods are an efficient, reliable means to produce genetically engineered T cells with a high degree of success. |
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Bibliography: | Application Number: MA20180050855 |