COMPOSÉ DE PROLINEAMIDE SUBSTITUÉ PAR UN PHÉNYLDIFLUOROMÉTHYLE

[Problem]To provide a compound useful as a cathepsin S inhibitor.[Means for Solution]The present inventors have examined a compound that has a cathepsin S inhibitory effect and is usable as an active ingredient of a pharmaceutical composition for preventing and/or treating autoimmune disease includi...

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Bibliographic Details
Main Authors MATSUMOTO, Shunichiro, NAKAJIMA, Yutaka, HARAYAMA, Yu, IMADA, Sunao, TSUCHIYA, Kazuyuki, YAMAMOTO, Eriko
Format Patent
LanguageFrench
Published 17.03.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:[Problem]To provide a compound useful as a cathepsin S inhibitor.[Means for Solution]The present inventors have examined a compound that has a cathepsin S inhibitory effect and is usable as an active ingredient of a pharmaceutical composition for preventing and/or treating autoimmune disease including systemic lupus erythematosus (SLE) and lupus nephritis, allergies, or graft rejection of an organ, bone marrow or tissue, and have found that a phenyldifluoromethyl-substituted prolinamide compound of the present invention has the cathepsin S inhibitory effect, thereby completing the present invention. The phenyldifluoromethyl-substituted prolinamide compound of the present invention has the cathepsin S inhibitory effect and is useful as an agent for preventing and/or treating autoimmune disease including SLE and nephritis, allergies, or graft rejection of an organ, bone marrow or tissue.
Bibliography:Application Number: MA20180047380