مركبات عضوية

• Main Authors: LEWIS, SARAH, LIZOS, DIMITRIOS, FURMINGER, VIKKI, WEILER, SVEN, SHAW, DUNCAN, STIEFL, NIKOLAUS, JOHANNES, LEBLANC, CATHERINE, RITCHIE, CATHY, HORNSPERGER, BENOIT
• Format: Patent
• Language: Arabic; French
• Published: 01.10.2010
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La présente invention concerne des composés de formule (i) : sous une forme libre ou de sel ou de solvate, dans laquelle r1, r2, r3 et r20 ont les significations indiquées dans la spécification, qui sont utiles pour traiter des maladies induites par le récepteur alk-5 et/ou alk-4. L'invention concerne également des compositions pharmaceutiques qui contiennent les composés et des procédés de préparation des composés. Compounds of formula I: in free or salt or solvate form, where R1, R2, R3 and R20 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. These compounds are useful for the treatment of inflammatory or obstructive airways diseases such as pulmonary hypertension, pulmonary fibrosis, liver fibrosis, cancer, muscle diseases such as muscle atrophies and muscle dystrophies, and systemic skeletal disorders such as osteoporosis.