DERIVE POLYCYCLIQUE DE CINNAMIDE

• Main Authors: MIYAGAWA, TAKEHIKO, DOI, ERIKO, KIMURA, TEIJI, SATO, NOBUAKI, KANEKO, TOSHIHIKO, KAWANO, KOKI, DOKO, TAKASHI, ITO, KOICHI, TAKAISHI, MAMORU, HAGIWARA, HIROAKI, KITAZAWA, NORITAKA, SASAKI, TAKEO
• Format: Patent
• Language: French
• Published: 02.03.2009
• Edition: 7

«Composition pharmaceutique nouvelle» Il est révélé des compositions pharmaceutiques nouvelles contenant de l'acide 3'-[(2Z)-[1-(3,4-diméthylphényl)-1,5-dihydro-3-méthyl-5-oxo-4H-pyrazole-4-ylidène]hydrazino]-2'-hydroxy-[1,1'-biphényl]-3-carboxylique bis-(monoéthanolamine) (eltrombopag olamine) et des procédés pour leur préparation. Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar 1 represents an imidazolyl group which may be substituted by a C1-6 alkyl group, or the like, Ar 2 represents a phenyl group which may be substituted by a C1-6 alkoxy group, or the like, X 1 represents a double bond or the like, and Het represents an imidazolyl group which may be substituted by a C1-6 alkyl group, or the like. The compound or the salt is effective as a therapeutic or prophylactic agent for a disease associated with A².