DERIVES DU BIS-INDOLE AYANT UNE ACTIVITE ANTIMETASTASIQUE, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
The present invention relates to compounds of the general formula (I): wherein: R and R' are independently selected from hydrogen, hydroxy, chlorine, bromine, iodine, fluorine, (C1-C6)alkyl, (C1-C4)alkoxy, (C1-C4)acyloxy, amino, mono-(C1-C4)alkylamino, di-(C1-C4)alkylamino, -SH, (C1-C4)alkylthi...
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Main Authors | , , , , |
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Format | Patent |
Language | French |
Published |
20.12.2004
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to compounds of the general formula (I): wherein: R and R' are independently selected from hydrogen, hydroxy, chlorine, bromine, iodine, fluorine, (C1-C6)alkyl, (C1-C4)alkoxy, (C1-C4)acyloxy, amino, mono-(C1-C4)alkylamino, di-(C1-C4)alkylamino, -SH, (C1-C4)alkylthio, carboxy, (C1-C4)alkoxycarbonyl groups; R1 and R1' are independently selected from hydrogen, hydroxy, hydroxymethyl, amino, carboxy, (C1-C4)alkyl groups; A is a phenyl or naphtyl group substituted by at least one group selected from hydoxy, carboxy, -SH, -CONHOH or -PO3H2 group, or is a 5- or 6-membered heterocycle containing one or two heteroatoms selected from oxygen, nitrogen or sulfur, which can be optionally benzocondensed and/or substituted by at least one group selected from pyridyl, -SH, -PO3H2, carboxy or CONHOH, or is a group of formula -(CH2)n-X, in which n is zero or the integers 1 or 2, and X is selected from -SH -PO3H2, -CONHOH, carboxy, amino, mono-(C1-C4)alkylamino, di-(C1-C4)alkylamino, enantiomers, diastereoisomers, racemates and mixtures thereof, as well as salts thereof with pharmaceutically acceptable acids and bases, as antitumor and antimetastatic agents. l |
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Bibliography: | Application Number: MA19980025125 |