17-BETA-CARBOXANILIDES OF 4-AZA-5-ALPHA-ANDROSTAN-3-ONES AS 5-ALPHA-REDUCTASE INHIBITORS

This invention relates to novel anilide derivatives of 17-beta-carboxy-4-aza-5-alpha-androstan-3-ones that are useful for inhibiting the 5-alpha-reductase enzyme in prostatic tissue and isozymes thereof. They are also especially effective in selectively inhibiting mammalian 5-alpha-reductase for the...

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Bibliographic Details
Main Authors BAKSHI,RAMAN, K, RASMUSSON,GARY H, PATEL,GOOL, F
Format Patent
LanguageEnglish
Latvian
Published 20.12.2001
Edition7
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:This invention relates to novel anilide derivatives of 17-beta-carboxy-4-aza-5-alpha-androstan-3-ones that are useful for inhibiting the 5-alpha-reductase enzyme in prostatic tissue and isozymes thereof. They are also especially effective in selectively inhibiting mammalian 5-alpha-reductase for the treatment of benign prostatic hyperplasia in humans and dogs, acne, female hirsutism, androgenic alopecia, that is, male pattern baldness and treatment of prostatic carcinoma.
Bibliography:Application Number: LV20010000088