Glutamatdehidrogenazes beta-n-acetilheksoz-aminidazes un gamma-aktina genu promoteri un to izmantosana hifomicetu ekspresijas sekrecijas un antisenses sistemas

The invention relates to promoters of the genes glutamate desydrogenase, beta-acetylhexosaminidase and gamma-actine and their use in systems of expression, secretion and anti-sens of filamentary funghi. The invention also relates to the use of the promoters of the genes which code: (I) glutamate des...

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Main Authors FRANCISCO SALTO MALDONADO, BRUNO DIEZ GARCIA, MIGUEL ANGEL MORENO VALLE, ALFONSO J. COLLADOS DE LA VIEJA, JOSE LUIS BAREDO FUENTE, MARTA RODRIGUEZ SAIZ
Format Patent
LanguageLatvian
Published 20.04.1999
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to promoters of the genes glutamate desydrogenase, beta-acetylhexosaminidase and gamma-actine and their use in systems of expression, secretion and anti-sens of filamentary funghi. The invention also relates to the use of the promoters of the genes which code: (I) glutamate desydrogenase NADP depending (EC.1.4.1.4) of Penicillium chrysogenum , (II) gamma-N-actylhexosaminidase (EC.3.2.1.52) of Penicillium chrysogenum and (III) gamma-actine of Penicillium chrysogenum and Acrimonium chrysogenum , which can be used for the construction of potent vectors of expression and secretion useful both for P. chrysogenum and for A. chrysogenum and related species. Said promoters can also be used for blocking the genic expression through anti-sens construction. Under the control of the above mentioned promoters, it is possible to conduct the expression of other genes in filamentary fungi, thereby increasing the production of antibiotics and/or proteins inherent to the same.
Bibliography:Application Number: LV19980000268