N-etoksikarbonil-3-morfolino-sidnonimina un ta salu iesleguma kompleksi ar ciklodekstrinu vai ta atvasinajumiem to iegusana un tos saturosas farmaceitiskas kompozicijas

Clathrates (I) of N-ethoxycarbonyl-3- morpholino-sydnonimine (II) or its salts with cyclodextrin derivs. (III) are new. N.B., cpds. (III) include unsubstd. beta- and gamma-cyclodextrins. (II) is an anti-angina and anti-ischaemic agent (molsidomin) useful for prevention and treatment of angina pector...

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Main Authors MARIA VIKMON, ISTVAN HERMECZ, GAAL, JOZSEF, HORVATH, GABOR, AGNES HORVATH, SZEJTLI, JOZSEF, KATALIN MARMAROSI, IREN MUNKACSI
Format Patent
LanguageLatvian
Published 20.10.1994
Edition5
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:Clathrates (I) of N-ethoxycarbonyl-3- morpholino-sydnonimine (II) or its salts with cyclodextrin derivs. (III) are new. N.B., cpds. (III) include unsubstd. beta- and gamma-cyclodextrins. (II) is an anti-angina and anti-ischaemic agent (molsidomin) useful for prevention and treatment of angina pectoris. It also has antiarrhythmic, fibrinolytic, platelet aggregation inhibitory and hypotensive activity. Pref. (III) are selected from beta-cyclodextrin (BCD), gamma-cyclodextrin, heptakis-2,6,O-dimethyl -beta-cyclodextrin and hydroxypropyl- beta-cyclodextrin.
Bibliography:Application Number: LV19920000590