9-HYDRAZONO-6,7,8,9-TETRAHYDRO-4H-PYRIDO(1,2-A)-PYRIMIDIN-4-ON-DERIVATE UND VERFAHREN ZU IHRER HERSTELLUNG

• Main Authors: HORVATH A, BREINING T, HERMECZ I, VASVARI L, KOEKOESI J
• Format: Patent
• Language: German
• Published: 31.07.1980
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A process for the preparation of nitrogen bridgehead condensed pyrimidine compounds of the general formula I [wherein R represents hydrogen or lower alkyl; R1 represents hydrogen, lower alkyl, carboxy or a derivative thereof or styryl; R2 represents hydrogen or optionally substituted lower alkyl; R3 represents hydrogen, optionally substituted lower alkyl, aryl, aralkyl, halogen, carboxy or a derivative thereof, the group -(CH2)m-COOH (in which m is the integer 1, 2 or 3) or a carboxy derivative thereof, formyl, lower alkanoyl or a condensed thereof; R4 represents hydrogen, optionally substituted alkyl, aryl optionally substituted by one or more substituents, optionally substituted aralkyl, a heterocyclic group optionally substituted by one or more substituents, the group (CH2)m-Het (in which m is the integer 1, 2 or 3; Het is an optionally substituted heterocyclic group); R5 represents hydrogen, C1-6alkyl, aryl optionally substituted by one or more substituents, formyl, lower alkanoyl, optionally substituted aroyl or heteroaryl; or R4 and R5 together with the nitrogen therebetween represent an optionally substituted mono- or bicyclic heterocyclic ring optionally containing further heteroatom] and pharmaceutically acceptable salts, hydrates, stereoisomers, optically active isomers, geometrical isomers and tautomers thereof.