SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF

Described herein are methods of treating MC4R-related conditions, diseases, or disorders by administering compounds of Formula I:or their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein. Such conditions, diseases, or disorders include cachexia, ano...

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Main Authors SAMMONS, Matthew Forrest, GARNSEY, Michelle Renee, POLIVKOVA, Jana, YANG, Qingyi, BUTLER, Christopher Ryan, OGILVIE, Kevin Alexander, SMITH, Aaron Christopher
Format Patent
LanguageEnglish
Lithuanian
Published 25.09.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described herein are methods of treating MC4R-related conditions, diseases, or disorders by administering compounds of Formula I:or their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein. Such conditions, diseases, or disorders include cachexia, anorexia, or anorexia nervosa.
Bibliography:Application Number: LT2021IB054970T