C40-, C28-, AND C-32-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS

The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

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Bibliographic Details
Main Authors KISS, Gert, WON, Walter, SEMKO, Christopher Michael, LEE, Julie Chu-Li, GLIEDT, Micah James Evans, BURNETT, G. Leslie, PITZEN, Jennifer, AGGEN, James Bradley, THOTTUMKARA, Arun P, WANG, Gang, CREGG, James Joseph, GILL, Adrian Liam, MELLEM, Kevin T
Format Patent
LanguageEnglish
Lithuanian
Published 25.07.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.
Bibliography:Application Number: LTUS2019029737T