BENZYLAMINO SUBSTITUTED PYRIDOPYRIMIDINONES AND DERIVATIVES AS SOS1 INHIBITORS

The present invention encompasses compounds of formula (I)wherein the groups R1 to R4, A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especia...

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Main Authors RUDOLPH, Dorothea Ingrid, SAVARESE, Fabio, OSTERMEIER, Markus, GILLE, Annika, KOFINK, Christiane, STADTMUELLER, Heinz, BAUM, Anke, RAMHARTER, Juergen, HOFMANN, Marco Hans, WUNBERG, Tobias, GMACHL, Michael, GOEPPER, Stefan, SANTAGOSTINO, Marco, WIPPICH, Julian, FRANK, Markus
Format Patent
LanguageEnglish
Lithuanian
Published 10.05.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention encompasses compounds of formula (I)wherein the groups R1 to R4, A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
Bibliography:Application Number: LTEP2018086197T