KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

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Bibliographic Details
Main Authors CHRISTENSEN, James, SAVECHENKOV, Pavel, COOK, Adam, FISCHER, John, BLAKE, James, RODRIGUEZ, Martha, BURGESS, Laurence, FELL, Jay, MEJIA, Macedonio, MARX, Matthew, SMITH, Christopher, CHICARELLI, Mark, VIGERS, Guy, TANG, Tony Pisal
Format Patent
LanguageEnglish
Lithuanian
Published 10.05.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
Bibliography:Application Number: LT2018US061060T