FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING SAME

The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment...

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Main Authors KULMAN, John, LIU, Tongyao, STEMMER, Willem, WANG, Chia-wei, VARFAJ, Fatbardha, CHANG, Pei-yun, TOBY, Garabet, JIANG, Haiyan, GEETHING, Nathan, WANG, Deping, DING, Sheng, SCHELLENBERGER, Volker, PETERS, Robert, SILVERMAN, Joshua, MEI, Baisong, SPINK, Benjamin
Format Patent
LanguageEnglish
Lithuanian
Published 10.01.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor Vlll-related diseases, disorders, and conditions.
Bibliography:Application Number: LT19165518T