A METHOD FOR PREPARING A SUBSTANTIALLY DIASTEREOMERICALLY PURE PHOSPHORODIAMIDATE OLIGOMER, A PHOSPHORODIAMIDATE OLIGOMER MADE BY SUCH A METHOD AND A PHARMACEUTICAL COMPOSITION COMPRISING SUCH A PHOSPHORODIAMIDATE OLIGOMER

We provide diastereomerically pure or substantially diastereomerically pure activated phosphoramidochloridate morpholino nucleosides, methods of their preparation, and methods of their use in stereospecific coupling for stereospecific synthesis of diastereomerically pure phosphorodiamidate morpholin...

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Bibliographic Details
Main Authors ENDO, Atsushi, CHOI, Hyeong Wook, SHAN, Mingde, FANG, Francis, YU, Robert T
Format Patent
LanguageEnglish
Lithuanian
Published 25.02.2022
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Summary:We provide diastereomerically pure or substantially diastereomerically pure activated phosphoramidochloridate morpholino nucleosides, methods of their preparation, and methods of their use in stereospecific coupling for stereospecific synthesis of diastereomerically pure phosphorodiamidate morpholino oligomers (PMOs)
Bibliography:Application Number: LT16045876T