BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AS NOTCH INHIBITORS

Disclosed are compounds of Formula (I) and/or salts thereof: wherein R1 is -CH2CH2CF3; R2 is -CH2CH2CF3 or -CH2CH2CH2CF3; R3 is H, -CH3, or Rx; R4 is H or Ry; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit...

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Bibliographic Details
Main Authors GAVAI, Ashvinikumar V, FINK, Brian E, ZHAO, Yufen, LEE, Francis Y, DELUCCA, George V, GILL, Patrice, QUESNELLE, Claude A, O`MALLEY, Daniel
Format Patent
LanguageEnglish
Lithuanian
Published 27.03.2017
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed are compounds of Formula (I) and/or salts thereof: wherein R1 is -CH2CH2CF3; R2 is -CH2CH2CF3 or -CH2CH2CH2CF3; R3 is H, -CH3, or Rx; R4 is H or Ry; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer; or as prodrugs of such compounds.
Bibliography:Application Number: LT13770806T