22(R,S)-11BETA,21 -DIHIDROKSI-16ALPHA, 17-BUTILIDENBICOKSIPREGNA-1,4-DIEN-3, 20-DIONO GAVIMO BUDAS

The invention relates to the steroids particularly to obtaining 22(R,S)-11β, 21-dihidroxi-16a, 17 butylidenbisoxipregn-1,4-dien-3,20 dion which has a pharmacological action on organism. The goal of the invention is to obtain this product with a desired isomer ratio. The synthesis is made by reaction...

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Main Authors FORGACS,LILLA, SZPORNY,LASZLO, MAJOR,PIROSKA, MOLNAR,CSABA, TOTH,JOZSEF, BOOR,ANNA, KIRALY,ARPAD, HAJOS,GYORGY, FEKETE,GYORGY, HERENYI,BULCSU
Format Patent
LanguageLithuanian
Published 15.10.1993
Edition5
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:The invention relates to the steroids particularly to obtaining 22(R,S)-11β, 21-dihidroxi-16a, 17 butylidenbisoxipregn-1,4-dien-3,20 dion which has a pharmacological action on organism. The goal of the invention is to obtain this product with a desired isomer ratio. The synthesis is made by reaction 11β, 16a, 17-trihydroxi-21 acetoxi-pregn-1,4-dien-3,20-dion 16,17-ether metilyc of cicloortobornic acid with n-butiraldehyde, the molar ratio is 1:2, in the tetrahydrofuran medium in the presence of anhydride acetic at room temperature, saponifing the obtained product in the presence of perchloric acid. In this case a product is obtained with the isomer ratio 22R:S 1:1 with purity up to 96%.
Bibliography:Application Number: LTRP857