CEPHALSOPORINS DERIVATIVES

Cephalosporin compound(I), its avirulent salt, ester, hydrate, solvation, and its isomer are claimed. Thus, title compound(I) and its derivatives are prepared by reacting compound(II) with compound(III) in the presence of solvent followed by reduction of S-oxide S->(O)n at 10-80 deg.C. In formula...

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Main Authors BANG, CHAN-SIK, KIM, SUNG-ILL, WOO, YOUNG-MIN, YEU, JAE-HONG, CHON, JAE-HOON, LIM, JONGAN, YANG, DUK-HO, OH, HUN-SEUNG, KIM, YONG-JOO, KIM, SAM-SIK, LEE, TAE-HEE, KIM, SE-HO
Format Patent
LanguageEnglish
Korean
Published 21.04.1997
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Cephalosporin compound(I), its avirulent salt, ester, hydrate, solvation, and its isomer are claimed. Thus, title compound(I) and its derivatives are prepared by reacting compound(II) with compound(III) in the presence of solvent followed by reduction of S-oxide S->(O)n at 10-80 deg.C. In formula, R1 is H or amino protecting group, R2,R3 are H or hydroxy protecting group, R4 is H or hydroxy protecting group, R5 is H, C1-4 alkyl, alkoxycarbonyl, carboxyl, or sulfurmethyl, R6 is H, amino or C1-4 alkyl substituted amino group, R7 is C1-4 alkyl, amino group or C1-4 alkyl substituted amino group, R8 is H or carboxyl protecting group, Q is CH or N, m is 0 or 1, L is leaving group.
Bibliography:Application Number: KR19930014063