PROCESS FOR PREPARING FLORFENICOL, ITS ANALOGS AND OXAZOLINE INTERMEDIATES THERETO

PCT No. PCT/US91/07608 Sec. 371 Date Apr. 22, 1993 Sec. 102(e) Date Apr. 22, 1993 PCT Filed Oct. 23, 1991.A process for preparing a compound of formula (IV): (IV) comprising a) contacting an oxazoline compound of formula (I): (I) wherein Z is as defined hereinbefore, with a reagent capable of causin...

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Bibliographic Details
Main Authors SCHUMACHER, DORIS P, CLARK, JOHN E, WU, GUANG - ZHONG
Format Patent
LanguageEnglish
Published 28.06.1996
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PCT No. PCT/US91/07608 Sec. 371 Date Apr. 22, 1993 Sec. 102(e) Date Apr. 22, 1993 PCT Filed Oct. 23, 1991.A process for preparing a compound of formula (IV): (IV) comprising a) contacting an oxazoline compound of formula (I): (I) wherein Z is as defined hereinbefore, with a reagent capable of causing an equilibrium between oxazoline compound (I) and an oxazoline compound of formula (II) described herein, and the reagent drives the equilibrium toward oxazoline compound (II) by preferential precipitation of oxazoline compound (II); b) contacting compound (II) with a fluorinating agent to give a fluorinated oxazoline compound of formula (III) described herein; and c) hydrolyzing the compound of formula (III) to formula (IV). In an alternative embodiment, the process is directed toward a process for preparing oxazoline (II) in a single step.
Bibliography:Application Number: KR19930701226