3,5-DIHSDROXYHEPTANOIC ACID DERIVATIVES

3,5-Dihydroxyheptanoic acid derivatives of formula (I) and formula (II) have an inhibition effect on HMG-CoA reductase, a cholesterol value reduction effect, and an antioxidation function, thus serving as cholesterol reducing agent or lipid reducing agents: wherein R represents hydrogen, a nitro gro...

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Main Authors AOYAMA, MISAO, MATSUMOTO, MASAKATSU, YAMAURA, TETSUAKI, MORI, EIKO, WATANABE, NOBUKO
Format Patent
LanguageEnglish
Korean
Published 02.10.1995
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:3,5-Dihydroxyheptanoic acid derivatives of formula (I) and formula (II) have an inhibition effect on HMG-CoA reductase, a cholesterol value reduction effect, and an antioxidation function, thus serving as cholesterol reducing agent or lipid reducing agents: wherein R represents hydrogen, a nitro group, or -N(R4)R5 in which R4 and R5 each represent an alkyl group, an alkenyl group, an aryl group, an aralkyl group; an acyl group, an aroyl group, a carbamoyl group, or a thiocarbamoyl group, and R4 and R5 may be combined to form a cyclic amino group; and R and R each represent hydrogen or an alkyl group; and R6 represents hydrogen, an alkyl group, an alkali metal, or an alkaline earth metal.
Bibliography:Application Number: KR19920016903