6-SUBSTITUTED ACYCLIC PYRIMIDINE NUCLEOSIDE DERIVATIVES AND ANTIVIRAL AGENTS CONTAINING THE SAME AS ACTIVE INGREDIENTS

• Main Authors: BABA, MASANORI, TANAKA, HIOMICHI, UBASAWA, MASARU, DECLERCQ, ERICK D. A, MIYASAKA, TADASHI, WALKER, RICHARD T
• Format: Patent
• Language: English; Korean
• Published: 21.06.1995
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

6-Substitued acyclicpyrimidine nucleoside derivatives represented by general formula (I) (wherein R represents a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, an alkylcarbonyl group, an arylcarbonyl group, an arylcarbonylalkyl group, an arylthio group or an aralkyl group, R represents an arylthio group, an alkylthio group, a cycloalkylthio group, an arylsulfoxido group, an alkylsulfoxido group, a cycloalkylsulfoxido group, an alkenyl group, an alkynyl group, an aralkyl group, an arylcarbonyl group, an arylcarbonylalkyl group or an aryloxy group, R represents a hydroxyalkyl group whose alkyl moiety may be interrupted by an oxygen atom, X represents an oxygen atom, a sulfur atom or an amino group, Y represents an oxygen atom or a sulfur atom, and A represents =N- or -NH-) or pharmaceutically acceptable salts thereof, a process for preparing these compounds, and antiviral agents containing the compounds as active ingredients are disclosed.