PROCESS FOR THE SYNTHESIS OF THE ALPHA-(1-METHYLETHYL)-3,4-DIMETHOXYBENZENE-ACETONITRILE

New process for the synthesis of the alpha -(1-methylethyl)-3,4-dimethoxyacetonitrile of formula intermediate in the synthesis of the drug internationally known as verapamil. The process starts from the isobutyryl-3,4-dimethoxybenzene of formula which, by means of the Darzens condensation, gives an...

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Bibliographic Details
Main Authors TAMERLANI, GIANCARLO, CANNATA, VINCENZO, ZAGNONI, GARZIANO
Format Patent
LanguageEnglish
Korean
Published 27.12.1994
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:New process for the synthesis of the alpha -(1-methylethyl)-3,4-dimethoxyacetonitrile of formula intermediate in the synthesis of the drug internationally known as verapamil. The process starts from the isobutyryl-3,4-dimethoxybenzene of formula which, by means of the Darzens condensation, gives an epoxyester which, by alkaline hydrolysis and subsequent decarboxylation, gives the alpha -(1-methylethyl)-3,4-dimethoxybenzeneacetaldehyde. This product is reacted with hydroxylamine so obtaining the corresponding oxime that, by dehydratation, gives the nitrile of formula I.
Bibliography:Application Number: KR19880003818