PROCESS FOR PRODUCING QUINOLON-CARBOXYLIC ACID DERIVATIVES

• Main Authors: SUZUE, SEIGO, HIRAI, KEIJI, ISHIZAKI, TAKAYOSHI, MASUZAWA, KUNIYOSHI
• Format: Patent
• Language: English
• Published: 14.10.1994
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Quinolonecarboxylic acid derivatives of the following formula, wherein R indicates straight or branched lower alkyl, R1 indicates cycloalkyl having 3 to 6 carbon atoms, straight or branched lower alkyl, halogenoalkyl, alkenyl, hydroxyalkyl, lower alkylamino or substituted or non-substituted phenyl, R2 indicates hydrogen, halogen, nitro or amino, X indicates halogen, Z indicates halogen, azetidino, pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino or homopiperazino of the following formula, (here, n is 1 or 2, R3 indicates hydrogen, lower alkyl, lower acyl, acyloxycarbonyl or benzyl, R4 and R5 indicate hydrogen, lower alkyl, aminoalkyl, hydroxyalkyl or phenyl each independently), or pyrrolidino or piperidino of the following formula, (here, k is 0, 1 or 2, l is 0, 1 or 2, m is 0 or 1, R6 indicates hydrogen, lower alkyl or hydroxy, R7 indicates hydrogen, lower alkyl, halogenoalkyl or hydroxyalkyl, R8 indicates hydrogen, lower alkyl, lower acyl, alkoxycarbonyl or benzyl), the hydrates and pharmaceutically acceptable acid addition or alkali salts thereof are useful as antibacterial agents.