PROCESS AND PRODUCTION OF PYRIMIDINE DERIVATIVES

The method for preparing 3,5-dimethyl-4-methoxy pyridine-N-oxide of formula (I) comprises (a) reacting 3,5-dimethyl pyridine-N-oxide of formula (III) with a halogenating agent 50 obtain 3,5-dimethyl-4-halopyridine-N-oxide of formula (II); and (b) reacting (II) with a base. In the formulas, X = chlor...

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Bibliographic Details
Main Authors MUN, SUN - KU, KIL, YONG - HWAN, LEE, KWAN - SUN
Format Patent
LanguageEnglish
Korean
Published 09.06.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The method for preparing 3,5-dimethyl-4-methoxy pyridine-N-oxide of formula (I) comprises (a) reacting 3,5-dimethyl pyridine-N-oxide of formula (III) with a halogenating agent 50 obtain 3,5-dimethyl-4-halopyridine-N-oxide of formula (II); and (b) reacting (II) with a base. In the formulas, X = chloro or bromo. The halogenating agent is N-halosuccinimide of formula (IV). And the base is pref. claisen base (KOH-MeOH- H2O). The cpd. (I) is useful as an intermediate in the prodn. of omeprazole.
Bibliography:Application Number: KR19910020103