NOVEL ALPHA-DIARYL-4-ARYL-4-HYDROXY-1-PIPERIDINEBUTANAAMIDE-N-OXIDES

Novel alpha , alpha -diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides of formula wherein R is hydrogen or methyl; Ar and Ar are, each independently, phenyl or halophenyl; Alk is -CH2-CH2- or -CH2-CH(CH3)-; R and R are, each independently, hydrogen, C1-6alkyl, phenylmethyl or 2-propenyl or R...

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Bibliographic Details
Main Authors WALS, LOWRENS, COOYMANS, LUDWIG P
Format Patent
LanguageEnglish
Korean
Published 05.03.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel alpha , alpha -diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides of formula wherein R is hydrogen or methyl; Ar and Ar are, each independently, phenyl or halophenyl; Alk is -CH2-CH2- or -CH2-CH(CH3)-; R and R are, each independently, hydrogen, C1-6alkyl, phenylmethyl or 2-propenyl or R and R combined with the nitrogen atom bearing said R and R may form a pyrrolidinyl, piperidinyl, C1-6alkylpipridinyl, 4-morpholinyl or 2,6-di(C1-6alkyl)-4-morpholinyl radical; Ar is phenyl being optionally substituted with up to 3 substituents selected from the group consisting of C1-6alkyl, C1-6alkyloxy, halo and trifluoromethyl; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-diarrheal agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
Bibliography:Application Number: KR19860008184