ANALOGS OF ATRIAL NATRIURETIC PEPTIDES

Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides have of the formula: Z1-AA8-AA9-AA10-AA11-AA12-Z2 wherein: each of AA8 and AA11 is, independently, a basic/non-cyclic or neutral/non-polar/small or neutral/polar/non-cyclic amino acid residue: each of AA9 and AA12...

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Bibliographic Details
Main Authors JOHNSON, LORINK, SCARBOROUGH, ROBERT, LEWICKI, JOHN A
Format Patent
LanguageEnglish
Korean
Published 05.03.1994
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides have of the formula: Z1-AA8-AA9-AA10-AA11-AA12-Z2 wherein: each of AA8 and AA11 is, independently, a basic/non-cyclic or neutral/non-polar/small or neutral/polar/non-cyclic amino acid residue: each of AA9 and AA12 is, independently, a neutral/nonpolar/non-cyclic amino acid residue in the D- or L- configuration; AA10 is an acidic amino acid residue; and together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriuretic Peptides.
Bibliography:Application Number: KR19870700587