PROCESS FOR PREPARING 2-METHYL-4-ISOTHIAZOLINE-3-ONE

The method for preparing 2-methyl-4-isothiazoline-3-one HCl of formula (I) comprises (a) reacting 3,3'-dithiodipropionic acid with thionyl chloride to form 3,3'-dithiodipropionyl dichloride, (b) reacting it with methylamine to obtain N,N'-dimethyl-3,3'-dithiodipropion amide of fo...

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Bibliographic Details
Main Authors HAN, SUN - JONG, KIM, JIN - MAN
Format Patent
LanguageEnglish
Korean
Published 12.01.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The method for preparing 2-methyl-4-isothiazoline-3-one HCl of formula (I) comprises (a) reacting 3,3'-dithiodipropionic acid with thionyl chloride to form 3,3'-dithiodipropionyl dichloride, (b) reacting it with methylamine to obtain N,N'-dimethyl-3,3'-dithiodipropion amide of formula (III), and (c) reacting (III) with sulfryl halide (IV) in an organic solvent at -20 - 10 deg.C. Pref. the molar ratio of (III):(IV) is 1:2 - 1:3.7; the organic solvent is selected from CH2X2, CHX3, CHX2CHX2 or CX3CH3 CX= halogen).
Bibliography:Application Number: KR19910007541