TETRAHYDROBENZIMIDAZOLE DERIVATIVES AND PROCESS FOR PREPARATION THEREOF

Tetrahydrobenzimidazole derivatives represented by formula (I) : wherein Het represents a heterocyclic group which may be substituted with 1 to 3 substituents selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl-lower alkyl group, an a...

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Main Authors KOIDE, TOKUO, MIYATA, KEIJI, YANAGISAWA, ISAO, MATSUHISA, AKIRA, OHTA, MITSUAKI, OMORI, JUNYA, SUZUKI, TAKESHI
Format Patent
LanguageEnglish
Korean
Published 20.11.1993
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Tetrahydrobenzimidazole derivatives represented by formula (I) : wherein Het represents a heterocyclic group which may be substituted with 1 to 3 substituents selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl-lower alkyl group, an aralkyl group, a lower alkoxy group, a nitro group, a hydroxyl group, a lower alkoxycarbonyl group, and a halogen atom; and X represents a single bond or -NH- which is bonded to a carbon atom or nitrogen atom of the heterocyclic ring, and pharmaceutically acceptable salts thereof. These compounds exhibit antagonism against 5-HT3 receptor.
Bibliography:Application Number: KR19900001039