PROCESS FOR PREPARING CEPHEM COMPOUND

3-Pyridinium methyl-7-thiazolyl acetamido cephalosporin cpds. of formula (I) and their physiologically acceptable acid addition salts are prepd. by reacting 3-substd. methyl cephalosporin cpds. of formula (II) with pyridine bases in the presence of trialkylsilyl trihalomethane sulfonate of formula (...

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Bibliographic Details
Main Authors MUN, SUN - KU, HONG, KU - YOL, KIM, YONG - RIP, YU, SUNG - WON, LEE, KWAN - SUN
Format Patent
LanguageEnglish
Korean
Published 20.08.1993
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:3-Pyridinium methyl-7-thiazolyl acetamido cephalosporin cpds. of formula (I) and their physiologically acceptable acid addition salts are prepd. by reacting 3-substd. methyl cephalosporin cpds. of formula (II) with pyridine bases in the presence of trialkylsilyl trihalomethane sulfonate of formula (III). This process gives (I) in good yield. In formula (I) (syn isomer), R1=H, CH3 or -CRaRbCOOH (Ra,Rb=H,CH3); Q= pyridinium, 2,3-cyclopenteno-1-pyridinium or 2,3-cyclohexeno-1-pyridinium.
Bibliography:Application Number: KR19910024763