BUTEROIC ACID AMIDES, THEIR SALTS, PHARMACETUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME

Compounds of the general formula (I), wherein R is hydrogen, halogen, C1-4alkyl, C1-4alkoxy or C1-4acylamino group; R1 is hydrogen or a carboxyl-protective group; and R2 represents a -(CH2)n-CO2R5 group, wherein n is 1, 2, 3 or 4; and R5 is hydrogen or a carboxyl-protective group; or R2 is a -(CH2)n...

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Main Authors FODOR, TAMAS, DOBAY, LASZIO, SZPORNY, LASZLO, EZER, ELEMER, STEFKO, BEIA, SAGHY, KATALIN, MATUZ, JUDLT, FISHER, JANOS
Format Patent
LanguageEnglish
Korean
Published 08.07.1993
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of the general formula (I), wherein R is hydrogen, halogen, C1-4alkyl, C1-4alkoxy or C1-4acylamino group; R1 is hydrogen or a carboxyl-protective group; and R2 represents a -(CH2)n-CO2R5 group, wherein n is 1, 2, 3 or 4; and R5 is hydrogen or a carboxyl-protective group; or R2 is a -(CH2)n-NH2 group, wherein n is 1, 2, 3 or 4 in the E and/or Z configuration, as well as their salts, show a cytoprotective effect and promote the healing of stomach ulcers. Their toxicity is low.
Bibliography:Application Number: KR19880012389