PROCESSING FOR STYRENE PERIVATIVES

Novel styrene derivatives of the general formula I wherein X is hydrogen or halogen, X1 is halogen, R is hydrogen or methyl, Y is hydroxymethyl, carboxyl, -COOR1 or -COR2 wherein R1 is prenyl, geranyl, farnesyl, cyclohexyl, phthalidyl, straight or branched chain alkyl having 1 to 6 carbon atoms, or...

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Bibliographic Details
Main Authors SANO TATSUHIKO, YOSHIKAWA KENSEI, OHUCHI YUTAKA, SOTA KAORU, SEKIUCHI KAZUTO, OTA TOMOMI, HATAYAMA KATSUO
Format Patent
LanguageEnglish
Korean
Published 20.08.1991
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel styrene derivatives of the general formula I wherein X is hydrogen or halogen, X1 is halogen, R is hydrogen or methyl, Y is hydroxymethyl, carboxyl, -COOR1 or -COR2 wherein R1 is prenyl, geranyl, farnesyl, cyclohexyl, phthalidyl, straight or branched chain alkyl having 1 to 6 carbon atoms, or said alkyl substituted with hydroxy, methoxy, pyridyl or alkanoyloxy having 2 to 16 carbon atoms, and R2 is amino, hydroxyamino mono-(or di-)alkylamino in which the alkyl moiety contains 1 or 2 carbon atoms, ethoxycarbonylmethylamino, carboxymethylamino, thiazolylamino, cyclohexylamino, pyridylamino, morpholino, N-methylpiperazino, phenylamino, phenylamino substituted with one or two of halogen, hydroxy, methyl, methoxy, trifluoromethyl or carboxyl at the phenyl ring, and the pharmaceutically acceptable salts thereof when Y is carboxyl are disclosed. These compounds exhibit high and long-lasting anti-inflammatory, analgesic and anti-pyretic activity.
Bibliography:Application Number: KR19840002573