THE METHOD OF PIPERIDINE DERIVATIVE

A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula:in which R1 is a lower alkyl or a tolyl, R2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl,...

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Main Authors SHOJI TADAO, MIYAKE KAZUTOSHI, NOMOTO KEMICHI, HOSHIKO TOMONORI, OINUMA HITOSHI, YAMANAKA MOTOSUKE, MINAM NORIO, SAWADA KOBEI, DAIKU YOSHIHARU
Format Patent
LanguageEnglish
Korean
Published 26.04.1991
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula:in which R1 is a lower alkyl or a tolyl, R2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is -CO-, -CH2- or -CHOH-, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, -CH2COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl,1 being 1 or 2, -A-B, A being -(CH2)n-, n being an integer of 1 to 5,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl. group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,k being an integer of 2 to 5, - (CH2)p-CO-, p being an integer of 1 to 4, B being cyano, - NR4R5, a heterocyclic ring or a condensed aromatic ring. A pharmaceutical composition containing said compounds as active ingredient, and the use of said compound in the preparation of a medicament for the treatment of arrhythmia are also disclosed.
Bibliography:Application Number: KR19870001676