PROCESS FOR THE PREPARATION OF BENZOTHIO PYRANO-PYRIDINONES

Tetrahydro benzothiopyrano(2,3-C)pyridin-10-one(S) of formula (I) are prepd. by reacting (II) with (III) by heating in polyphosphoric acid. In the formulas, A, B, C and D are each H, C1-6 alkyl or -alkoxy, NO2 halo, NH2, C2-7 acylamino or A and B or C and D together with attached C atoms form benzen...

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Bibliographic Details
Main Authors AGER IAN R, ROWLANDS DAVID A, GILLESPIE ROGER J, JEWERY STEPHEN C, GARDENER COLIN R
Format Patent
LanguageEnglish
Korean
Published 20.09.1990
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Tetrahydro benzothiopyrano(2,3-C)pyridin-10-one(S) of formula (I) are prepd. by reacting (II) with (III) by heating in polyphosphoric acid. In the formulas, A, B, C and D are each H, C1-6 alkyl or -alkoxy, NO2 halo, NH2, C2-7 acylamino or A and B or C and D together with attached C atoms form benzene ring; R is C1-9 alkyl, C2-9 alkenyl opt. substd. by OH, C3-9 cycloalkyl, phenyl or C7-9 aralkyl; X is C1-8 alkyl. (I) are dopamine and alpha 2 receptor antagonists have anti- dopaminergic, antidepressant and antipsychotic activity.
Bibliography:Application Number: KR19830003209