PROCESS FOR PREPARING N-(2-METHOXYETHYL)-NOROXYMORPHONE

N-(2-Methoxyethyl)-noroxymorphoen of formula (I) and its acid addn. salts are prepd. by reacting noroxymorphone of formula (II) with a 2- methoxyethyl halide of formula X-(CH2)2-OCH3 where X is Cl, Br or I. (I) is useful as a non-addictive analgesic. It is a opioid-like agonist-antagonist with a non...

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Bibliographic Details
Main Authors LANGBEIN ADLOB, MERZ HERBERT, STOCKHAUS KLAUS
Format Patent
LanguageEnglish
Korean
Published 20.09.1990
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:N-(2-Methoxyethyl)-noroxymorphoen of formula (I) and its acid addn. salts are prepd. by reacting noroxymorphone of formula (II) with a 2- methoxyethyl halide of formula X-(CH2)2-OCH3 where X is Cl, Br or I. (I) is useful as a non-addictive analgesic. It is a opioid-like agonist-antagonist with a non-morphine like activity profile not found in known cpds. It is 36 times as active as morphine in the writhing test.
Bibliography:Application Number: KR19830002440