7 - (SUBSTITUTED) PIPERAZINYL-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACIDS AND THEIR PREPARATION

Cpds. of formula (I) and their salts, useful as antibacterials, are prepd. from 6,7-difluoro cpd. and substd. piperazine. In (I), R1= H, C1-3 alkyl, C1-3 dialkyl, C1-3 aminoalkyl, Npiperidinoalkyl, N- morpholinoalkyl, N-4-methylpiperidinoalkyl, Npiperazinyl, etc.; R2= C1-4 alkyl, C3-6 cycloalkyl, C1...

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Bibliographic Details
Main Authors ZIEGLER CARL B. JR, LIN YANG-L, SUM PHAIK-ENG, JOSEPH JOSEPH P, MORAN DANIEL B
Format Patent
LanguageEnglish
Korean
Published 06.08.1990
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Cpds. of formula (I) and their salts, useful as antibacterials, are prepd. from 6,7-difluoro cpd. and substd. piperazine. In (I), R1= H, C1-3 alkyl, C1-3 dialkyl, C1-3 aminoalkyl, Npiperidinoalkyl, N- morpholinoalkyl, N-4-methylpiperidinoalkyl, Npiperazinyl, etc.; R2= C1-4 alkyl, C3-6 cycloalkyl, C1-4 alkoxy, C1-3 alkylamino, vinyl, phenyl, benzyl, -CH2CH2F, etc.; R3= H, benzyl or C1-3 alkyl; R4= H, C1-3 alkyl, ethenyl, ethinyl, C3-6 cycloalkyl, fluoromethyl, hydroxynethyl, etc.; R5= H or F; A is =N-, =CH- or =CF-.
Bibliography:Application Number: KR19870000377