TETRAHYDRO-BENZO (E) ISOINDOLINES

A compd. of the 3a, 4, 5, 9b-tetrahydrobenzo[e -isoindoline[I; R, R1, R2 are independently selected from H, OH, C1-3 alkoxy, or R and R1, or R1 and R2 can be taken together to form methyleneodioxy or ethylenedioxy bridge; with proviso that at least one of R, R1 or R2 must be other than H; and R3 is...

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Bibliographic Details
Main Authors DEBERNAROYS JAHN F, MCCLELLAN WILLIAM J, CALKMAN DANIEL J
Format Patent
LanguageEnglish
Korean
Published 28.02.1990
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compd. of the 3a, 4, 5, 9b-tetrahydrobenzo[e -isoindoline[I; R, R1, R2 are independently selected from H, OH, C1-3 alkoxy, or R and R1, or R1 and R2 can be taken together to form methyleneodioxy or ethylenedioxy bridge; with proviso that at least one of R, R1 or R2 must be other than H; and R3 is H, C1-4 alkyl, aralkyl, 1,4- benzodioxane), useful as antihypertensive agents and their intermediates, is prepd. by reduction of a compd. of 1,3-dioxo-3a, 4, 5, 9b-tetrahydro-benzo [e -isoindoline (II).
Bibliography:Application Number: KR19830002396