PIPERAZINYL DERIVATIVE AND THEIR PREPARATION

Piperazine derivs. of formula (I) are prepd. by reacting a cpd. of formula (II) with a cpd. of formula (III). In the formulas, Het is an opt. substd. 2-, 3- or 4-pyridyl gp., or 2-imidazolyl gp.; R is - NHSO2R3, -SO2NR1R2, nitro, amino or acetamido; R3 is C1-4 alkyl, C3-7 cycloalkyl or -NR1R2; R1 an...

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Bibliographic Details
Main Authors DICKINSON ROGER P, CROSS PETER E
Format Patent
LanguageEnglish
Korean
Published 28.06.1989
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Piperazine derivs. of formula (I) are prepd. by reacting a cpd. of formula (II) with a cpd. of formula (III). In the formulas, Het is an opt. substd. 2-, 3- or 4-pyridyl gp., or 2-imidazolyl gp.; R is - NHSO2R3, -SO2NR1R2, nitro, amino or acetamido; R3 is C1-4 alkyl, C3-7 cycloalkyl or -NR1R2; R1 and R2 are each H or C1-4 alkyl; X is - (CH2)m-, -CO(CH2)n- or -CH(OH)(CH2)n; m is 1-4; n is 1-3; Q is a leaving gp.. (I) are useful as antiarrhythmic agents.
Bibliography:Application Number: KR19870000955