PROCESS FOR PREPARING 5-(LOWER ALKYL)-1,6 NAPHTHYRIDIN-2(1H)-ONES

The title compds. (I) or its acid addn. salts are prepd. by reacting (II) with formamidine, ammonia or its salt. R, R1 and R2 are lower alkyl; R'=H or Me; R"=H or lower alkyl; Q=H, OH, amino, cyano, carbamyl, carboxy or amino carbamyl; Q'=H or cyano. (I) are useful as cardiotonic drug...

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Bibliographic Details
Main Authors LESHER GEORGE Y, SINGH BALDEV
Format Patent
LanguageEnglish
Korean
Published 14.05.1987
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The title compds. (I) or its acid addn. salts are prepd. by reacting (II) with formamidine, ammonia or its salt. R, R1 and R2 are lower alkyl; R'=H or Me; R"=H or lower alkyl; Q=H, OH, amino, cyano, carbamyl, carboxy or amino carbamyl; Q'=H or cyano. (I) are useful as cardiotonic drugs. The rxn. performed in the anhydrous condition. Q is carboxy and carbamyl compds. are produced from hydrolysis of Q is cyano compds., if necessary.
Bibliography:Application Number: KR19830003601