PREPARATION OF BENZENESULFONAMIDE DERIVATIVES

The title compds. (I; R1,R3=H, C1-3alkyl, halo, CF3; R2=halo, Me, CF3; R4=H, halo, Me, CF3), effective in the treatment of cancer are prepd. Thus, 4-methyl-N-[[(4-trifluoromethylphenyl) amino carbonyl benzenesulfonamide (II) is prepf. from 4-aminobenzotrifluoride and p- toluenesulfonyl isocyanate. (...

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Bibliographic Details
Main Authors RIEDER BRENT J, HARPER RICHARD W, POORE GERALD A
Format Patent
LanguageEnglish
Korean
Published 13.04.1987
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The title compds. (I; R1,R3=H, C1-3alkyl, halo, CF3; R2=halo, Me, CF3; R4=H, halo, Me, CF3), effective in the treatment of cancer are prepd. Thus, 4-methyl-N-[[(4-trifluoromethylphenyl) amino carbonyl benzenesulfonamide (II) is prepf. from 4-aminobenzotrifluoride and p- toluenesulfonyl isocyanate. (II) is tested in animals bearing various kinds of tumors and it shows antineoplastic effects. (I) can be administered by various routes, however, it is a special feature of the compds. that they are effective following oral administration. A hard gelatin capsule is formulated contg. (II) 250, starch 200, and Mg stearate 10mg/capsule.
Bibliography:Application Number: KR19850004552