PREPARATION OF BENZENESULFONAMIDE DERIVATIVES
The title compds. (I; R1,R3=H, C1-3alkyl, halo, CF3; R2=halo, Me, CF3; R4=H, halo, Me, CF3), effective in the treatment of cancer are prepd. Thus, 4-methyl-N-[[(4-trifluoromethylphenyl) amino carbonyl benzenesulfonamide (II) is prepf. from 4-aminobenzotrifluoride and p- toluenesulfonyl isocyanate. (...
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Main Authors | , , |
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Format | Patent |
Language | English Korean |
Published |
13.04.1987
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Edition | 4 |
Subjects | |
Online Access | Get full text |
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Summary: | The title compds. (I; R1,R3=H, C1-3alkyl, halo, CF3; R2=halo, Me, CF3; R4=H, halo, Me, CF3), effective in the treatment of cancer are prepd. Thus, 4-methyl-N-[[(4-trifluoromethylphenyl) amino carbonyl benzenesulfonamide (II) is prepf. from 4-aminobenzotrifluoride and p- toluenesulfonyl isocyanate. (II) is tested in animals bearing various kinds of tumors and it shows antineoplastic effects. (I) can be administered by various routes, however, it is a special feature of the compds. that they are effective following oral administration. A hard gelatin capsule is formulated contg. (II) 250, starch 200, and Mg stearate 10mg/capsule. |
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Bibliography: | Application Number: KR19850004552 |